Endocrine Abstracts

Introduction: Many thyroid conditions are associated with the development of a rapidly progressing goiter and should evoke several diagnoses, some of which may be of poor prognosis.Case-presentation: A 47-year-old female patient with no previous pathological history presented with a large goiter associated with a deteriorated general condition that had been evolving for 3 weeks On examination, she presented with a fever at 39°C, multiple cervical ad...

Introduction: 21-hydroxylase deficiency represents 95% of congenital adrenal hyperplasia. The non-classical form manifests in women mainly by hirsutism, menstrual disorders, or infertility. We present three patients’ cases.Observations: Patient N.C., 17 years old, who presented with hirsutism beginning at the age of 8 years and progressively worsening after puberty. The patient had her menarche at the age of 9 years, with short and irregular menses....

Introduction: Werner syndrome is a rare genetic disease affecting the WRN gene, of autosomal recessive inheritance.Case-presentation: We report the case of a 34-year-old patient who presented with erectile dysfunction and asthenia. His brother underwent surgery for meningioma. He was also diagnosed with hypogonadism, suffered from bilateral cataract and diabetes, and died following acute Leukemia at the age of 35 years. Our patient is from a second-degre...

Introduction: Cushing’s disease (CD), a hypercorticism caused by an ACTH-secreting pituitary adenoma, was associated with a 5-year survival of only 50%. Although advances in management have significantly reduced mortality, the results of transsphenoidal surgery, the gold standard in the treatment of CD, vary from patient to patient.Objective: The aim of our study is to evaluate the results of transsphenoidal surgery in CD (evolution, complications) ...

Introduction: Hirsutism is defined as excessive pilosity development in women in androgen-dependent areas. It is the main revealing sign of hyperandrogenism. It is a frequent reason for consultation in Endocrinology.Methods: This is a retrospective study of 82 records of patients hospitalized for exploration of hirsutism in the endocrinology department of Farhat Hached Hospital in Sousse, over a period of 20 years from 1997 to 2017.<p class="abstext"...

Introduction: During the COVID-19 pandemic, an increase of new-onset diabetes has been reported in various diabetes centers with many studies speculating an auto-immune-triggering mechanism while other studies hypothesizing an increase of type 2 diabetes (T2D).Aim: The aim of this study is to compare the type of new-onset diabetes presenting with a diabetic ketoacidosis and its prevalence in the pre-pandemic vs pandemic COVID-19.Me...

Introduction: COVID-19 has been incriminated directly and indirectly in the increase of patients presenting with diabetic ketoacidosis.Aim: The aim of this study is to compare diabetic ketoacidosis precipitating factors in the pre-pandemic and during the pandemic.Methods: This is a retrospective comparative study between patients hospitalized in the diabetology department in the university hospital Farhat Hached of Sousse for diabe...

BackgroundIt’s well known that smoking and diabetes are direct causes for serious health problems such as cancer, and atherosclerosis. It is suggested that smoking indirectly leads to atherosclerosis by influencing nutrient intakes as smokers tend to eat more fat and carbohydrates and less mono unsaturated fats and fiber than non-smokers. But no studies assessed the impact of tobacco on nutrition in diabetic patients.Aim<p...

BackgroundDiabetes Insipidus is a complex and heterogeneous clinical syndrome affecting water balance, resulting in large volumes of dilute urine. Determining the mechanism and etiology of diabetes insipidus, as well as differentiating it from other pathologies that cause polyuria and polydipsia has always been a challenge since water deprivation test is not always conclusive and antidiuretic hormone can not be reliably measured in the circulation.<p...

IntroductionSomatotropic adenomas in the elderly are rare, and characterized by diagnostic delay and non-specific clinical signs. We report three cases of acromegaly discovered at a late age.ObservationThey are three women aged 66, 68 and 77 respectively. The circumstance of discovery of acromegaly was goiter in the first case (P1), poorly controlled diabetes in the second case (P2) and dysmorphic syndrome in...